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In the parts of the city most frequented by tourists, it's easy to find someone that speaks English or even French, Italian or German. Some restaurants even have English menu. It's more difficult, but not impossible to find menus and signs in Japanese and Chinese. Due to the high number of students in Santiago, it's not difficult to find someone with a good level of English in the streets that will be willing to help.
The official languages of the city are Galician and Spanish. Galician is a language with great similarities with Portuguese, so speakers of this language will not have a lot of trouble understanding people.
